1. According to the strength of the role, it can be divided into two categories:
(1) Solvents with low surface tension and miscibility with water, including ethanol, propylene glycol, glycerin, dimethyl sulfoxide, etc.
(2) Surfactants, such as anionic surfactants, certain polyol-type surfactants (Span-type, Tween-type), polyoxyethylene-type surfactants.
2. According to the route of administration can be divided into three categories:
(1) Wetting agents used in external preparations include surfactants and alcohols with small surface tension and miscibility with water.
(2) Wetting agents for oral preparations include ethanol, glycerol, Tween, etc., which have low surface tension and ionic surfactants.
Anionic surfactants include alkyl sulfates, sulfonates, fatty acid or fatty acid ester sulfates, carboxylic acid soaps, phosphoric acid
Non-ionic surfactants include polyoxyethylene alkyl phenol ethers, polyoxyethylene fatty alcohol ethers, polyoxyethylare miscible with water.
(3) Wetting agents for injection, including ethanol, propylene glycol, glycerin, polyethylene glycol 200-400, etc., with low surface tension and miscibility with water, and Tween-80.
3. Divided into two categories according to the nature
Wetting agents include anionic and non-ene polyoxypropylene blocks
4. There is also a class of the latest type of silanol-based nonionic surfactants on the market, also known as wetting agents. Features: low molecular weight, multi-hydrophobic groups have an umbrella-shaped symmetrical structure. Compared with traditional active agents, wetting, Excellent permeability and high efficiency, it is a revolutionary new generation of surfactant. Very low dynamic and static surface tension, containing dihydroxy, reactive active agent, chemically inert, generally does not participate in the system's chemical reaction, good acid and alkali resistance, chemical stability. Typical models are: GSK-588 / 582/585 and other series.